| 摘要 |
A method of treating a subject in need of therapy for a condition involving detrimental activity of the enzyme core 2 GIcNAc-T is provided, comprising administration of a therapeutically effective amount of an inhibitor of core 2 GIcNAc-T of formula (I) to a patient in need thereof wherein: R1 is H, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6- alkoxy or C1-6 -alkoxy- C1-6-alkyl; R2 is H, - OH or C1-6 alkoxy; S1 and S2 are independently selected saccharide moieties; and Z is a steroid moiety; or a pharmaceutically acceptable salt, ether or ester thereof. |
