| 摘要 |
Molecular diversity technology using a combinatorial chemical method of a thiazole derivate is provided to easily test biological activation of a disease target by quickly producing a target compound with high purity by using a solution phase reaction. In a method for producing a thiazole derivate represented by formula(1) generated by combinatorially and chemically reacting compounds of a formula(A) or a formula(B) with compounds of a formula(C), R^a in the formula(1) is selected from a group comprising alkyl, cycloalkyl, heterocyclic which is not substituted or substituted for phenyl substituted as alkyl, alkenyl, alkynyl, alkoxy, and halogen of C1-C10. R^b is aliphatic and aromatic hydrocarbon derivate compounds of C5-C10 which are not substituted or substituted for C1 and alkoxy and includes straight or side chain alkyl, phenoxymethyl, substituted phenoxymethyl, aniline, C6H4NHCOR2(Anilide), and pyridine of C1-C8. R^c consists of hydrogen atom, CN(Cyano Group), C1, COOH(Carboxyl Group), methoxy, ethoxy, and CONHR3N(Amide). X contains sulfur atom, SO2(Sulfur Dioxide), NH, piperazine, and single-bond morpholine. R2 is phenyl or phenylmethyl substituted for alkyl or alkoxy. R3 is aliphatic and aromatic hydrocarbon derivate compounds of C5-C10 which are substituted or not substituted. |
