摘要 |
<p>The present invention relates to a method for the localization of at least one molecule associated with, or site of interest in, a sample nucleic acid, comprising the steps - Bringing at least one reporter complex, comprising at least one binding part showing specific binding to the molecule or the site of interest and at least one reporter nucleic acid, into contact with the sample nucleic acid, - Fragmenting the sample nucleic acid, - Enz ymatically ligating the reporter complex nucleic acid(s) to the sample nucleic acid, and - Detecting the hybrid ligation product. The invention also relates to libraries made with the method as well as microarrays of such libraries.</p> |