| 摘要 |
The invention relates to a method for the preparation of a stable, soluble amyloid beta (A.beta.) oligomer and composition thereof for use as an antige n for the generation of antibodies for the treatment of Alzheimer~s disease an d other conditions related to abnormal amyloid beta aggregation. The method which uses a pH in excess of 7.0 and high concentrations of A.beta., optionally includes the use of divalent anions or a helix-inducing solvent t o form the oligomers. The stable, soluble A.beta. oligomers produced by the method herein have a particle size of 10 to 100 nm in diameter, when measure d by a dynamic light scattering technique, and a molecular weight of 100 to 50 0 kDa.
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