| 摘要 |
PROBLEM TO BE SOLVED: To provide a closed-system circulatory circuit-type culturing device solving the following problems: in a conventional closed-system circulatory circuit-type culturing device, it is impossible to keep pH constant through controlling optimum culturing environment according to cell proliferation only by gas exchange; insertion of a lot of sensors results in being at high risk of interfusion of foreign matters; and it is necessary to make all the part getting in touch with blood disposable for being used for curing for medical use because use of an identical sensor to different patients has a risk of infection. SOLUTION: The closed-system circulatory circuit-type culturing device controls pH of culture soil in a culture soil reservoir with acidic gas so as to keep pH of the culture soil constant, detects deterioration in the culture soil based on addition of the acidic gas to be controlled so as to determine the time to exchange culture soil only with a pH sensor, and employs a noncontact-type pH sensor not directly getting in touch with the culture soil so as to eliminate the need for making the sensor disposable. COPYRIGHT: (C)2007,JPO&INPIT
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