The application relates to a polymeric prodrug which comprises a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on the surface of the hydrogel. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.
申请公布号
WO2006003014(A3)
申请公布日期
2007.01.11
申请号
WO2005EP07316
申请日期
2005.07.05
申请人
COMPLEX BIOSYSTEMS GMBH;HERSEL, ULRICH;RAU, HARALD;SCHNEPF, ROBERT;VETTER, DIRK;WEGGE, THOMAS
发明人
HERSEL, ULRICH;RAU, HARALD;SCHNEPF, ROBERT;VETTER, DIRK;WEGGE, THOMAS