METHOD FOR PREPARING A COVALENTLY CROSS LINKED OLIGOMER OF AMYLOID BETA PEPTIDES

摘要

The invention relates to a method for the preparation of a stabilized cross- linked oligomer of amyloid beta using a near-zero length bifunctional cross- linking agent for use as an immunogen for the generation of antibodies for t he treatment of Alzheimer~s Disease and other conditions related to abnormal amyloid beta aggregation. A preferred bifunctional cross-linking agent is 1, 5- difluoro-2,4-dinitrobenzene (DFDNB).