MODIFIED PYRROLOQUINOLINE QUINONE (PQQ)-DEPENDENT GLUCOSE DEHYDROGENASE HAVING EXCELLENT SUBSTRATE SPECIFICITY

摘要

PROBLEM TO BE SOLVED: To provide a modified PQQGDH (pyrroloquinoline quinone-dependent glucose dehydrogenase) improved in substrate specificity.

SOLUTION: The modified PQQGDH has a reduced activity to disaccharides (maltose) as compared with that of a wild type PQQGDH through modifying genes of a PQQGDH (pyrroloquinoline quinone-dependent glucose dehydrogenase) derived from Acinetobacter. The PQQGDH is expected to be utilized to accurate measurement of blood glucose.

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