<p>Disclosed herein are chimeric herpesviruses as well as methods of making and using such chimeric herpesviruses. The chimeric viruses comprise two nucleic acid sequences, one from a herpesvirus and one from a different virus. The herpesvirus nucleic acid sequence is a modified protein kinase R (PKR) evasion gene. The second viral nucleic acid sequence inhibits PKR-mediate protein shutoff in tumor cells, but is not neurovirulent. Thus, the chimeric virus has reduced neurovirulence as compared to the wild-type herpesvirus but remains replication competent.</p>
申请公布号
WO2007005876(A2)
申请公布日期
2007.01.11
申请号
WO2006US26052
申请日期
2006.06.30
申请人
THE UAB RESEARCH FOUNDATION;CASSADY, KEVIN, A.;MARKERT, JAMES, M.