PRODUCTION OF RECOMBINANT PRODUCTS USING CAPILLARY MEMBRANES

摘要

The invention provides for a method of producing at least one recombinant product under aerated conditions. The method includes providing a porous substrate having a first side and a second side and which has a biofilm of microorganisms attached to the first side thereof, the substrate being configured to allow passage of a nutrient solution therethrough and to preve nt the passage of microorganism cells therethrough. The method further includes causing a nutrient solution to flow through the substrate and the biofilm in a direction from the second side thereof to the first side thereof under aerat ed conditions, at a rate which is sufficiently low for a nutrient gradient havi ng a concentration differential to be established across the biofilm, and the microorganisms being induced to produce recombinant product.