发明名称 |
BIOFUNCTIONAL FIBERS |
摘要 |
The present invention is directed to surface functionalization of polymeric fibers. Surface biofunctionalization is achieved by covalent conjugation of biofunctional igands and/or cell growth factors that are crucial for cell attachment, proliferation and functions. Biofunctional fibers could be fabricated into three-dimensional scaffolds. Polymer fibers described here comprise of biocompatible polymers that are either biodegradable ornon-biodegradable. This patent also describes a series of new biodegradable polyphosphoramidates for the processing of biodegradable fibers. Scaffolds made of non-biodegradable functional fibers could be used for in vitro cell culture (for example, ex vivo cell expansion), while biodegradable functional fibers could be fabricated into tissue engineering scaffolds. |
申请公布号 |
EP1406680(A4) |
申请公布日期 |
2007.01.10 |
申请号 |
EP20020736456 |
申请日期 |
2002.06.14 |
申请人 |
JOHNS HOPKINS SINGAPORE PTE LTD |
发明人 |
HAI-QUAN, MAO;KUAN, CHEE, MUN;LEONG, KAM, WENG |
分类号 |
C12M1/00;A61K47/48;A61L27/00;A61L27/28;A61L27/38;A61L27/50;A61L27/54;C12N5/00;C12N5/071 |
主分类号 |
C12M1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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