| 发明名称 |
GENETIC MODIFICATION OF ENDOTHELIAL CELLS |
| 摘要 |
Endothelial cells transduced with genetic material encoding a polypeptide or protein of interest and, optionally, a selectable marker, as well as methods for making and using the transduced endothelial cells are disclosed. Such endothelial cells are useful in improving the performance of vascular grafts and in delivering the encoded polypeptide or protein, such as an enzyme, a hormone, a receptor or a drug, to an individual.
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| 申请公布号 |
CA2095153(C) |
申请公布日期 |
2007.01.09 |
| 申请号 |
CA19912095153 |
申请日期 |
1991.10.31 |
| 申请人 |
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH;SOMATIX THERAPY CORPORATION;BRIGHAM & WOMENS HOSPITAL;NEW ENGLAND MEDICAL CENTER HOSPITALS;HOWARD HUGHES MEDICAL INSTITUTE |
发明人 |
RAFIELD, LORI F.;COHEN, LAWRENCE K.;CALLOW, ALLAN D.;BIRINYI, LOUIS K.;WILSON, JAMES M.;MULLIGAN, RICHARD C. |
| 分类号 |
C12N5/10;C12N15/09;A61K31/70;A61K35/12;A61K38/00;A61K38/19;A61K38/37;A61K38/46;A61K38/49;A61K48/00;A61L27/00;A61L27/38;A61L33/00;A61L33/18;C07K14/635;C07K14/705;C07K14/755;C12N5/02;C12N5/071;C12N9/38;C12N9/64;C12N9/72;C12N11/02;C12N15/12;C12N15/867;C12P21/02;C12R1/91 |
主分类号 |
C12N5/10 |
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