发明名称 |
Integrin binding motif containing peptides and methods of treating skeletal diseases |
摘要 |
Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
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申请公布号 |
US7160862(B2) |
申请公布日期 |
2007.01.09 |
申请号 |
US20050042492 |
申请日期 |
2005.01.24 |
申请人 |
ACOLOGIX, INC. |
发明人 |
KUMAGAI YOSHINARI;YONEDA TOSHIYUKI;BLACHER RUSSELL WAYNE;NOMIZU MOTOYOSHI |
分类号 |
A61K9/08;A61K38/00;A61K8/00;A61K8/64;A61K9/70;A61K47/04;A61P3/00;A61P19/08;A61P19/10;A61Q11/00;C07K11/00;C07K14/00;C07K14/47;C07K14/705;C07K14/78 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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