发明名称 |
Peptide antagonists of DP transcription factors |
摘要 |
The invention provides a polypeptide consisting essentially of a sequence corresponding to residues 163 to 199 of DP-1 as shown in the Figure, and fragments and variants thereof capable of antagonizing the heterodimerization of a DP protein with an E2F protein. Such peptides may be used to induce apoptosis in a cell by introducing into the cell an effective amount of said peptide. Such cells include cardiovascular cells, and the peptide may be delivered in a stent to treat or prevent restinosis.
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申请公布号 |
US7160981(B2) |
申请公布日期 |
2007.01.09 |
申请号 |
US20010900147 |
申请日期 |
2001.07.09 |
申请人 |
PROLIFIX LIMITED |
发明人 |
LA THANGUE NICHOLAS B.;BANDARA LASANTHA R. |
分类号 |
C07K5/00;C12N15/09;A61F2/06;A61K38/00;A61K48/00;A61P17/06;A61P35/00;A61P35/02;A61P43/00;C07K14/47;C12N1/15;C12N1/19;C12N1/21;C12N5/10 |
主分类号 |
C07K5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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