| 发明名称 |
Hydroxyethylene compounds with Asp2 inhibitory activity |
| 摘要 |
The present invention relates to novel hydroxyethylene compounds having Asp2 (beta-secretase. BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated beta-amyloid levels or beta-amyloid deposits, particularly Alzheimer's disease.
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| 申请公布号 |
US7160905(B2) |
申请公布日期 |
2007.01.09 |
| 申请号 |
US20040496334 |
申请日期 |
2004.10.05 |
| 申请人 |
SMITHKLINE BEECHAM P.L.C. |
发明人 |
FALLER ANDREW;MILNER PETER HENRY;WARD JOHN GERARD |
| 分类号 |
A61K31/44;C07D333/40;A61K31/166;A61K31/381;A61K31/402;A61K31/41;A61P25/28;A61P43/00;C07C315/02;C07C317/42;C07C317/44;C07C317/46;C07D207/26;C07D207/27;C07D207/40;C07D211/72;C07D213/81;C07D333/12;C07D333/38 |
主分类号 |
A61K31/44 |
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