Synthesis of labeled compounds

摘要

The present invention is directed to labeled compounds of the formula Ar-Z₁-Q-Z₂ where Ar is an aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R₁, R₂, R₃, R₄ and R₅ are each independently selected from the group consisting of hydrogen, a C₁-C₄ lower alkyl, a halogen, a phenyl, an alkoxy group and an amino group from the group consisting of NH₂, NHR and NRR' where R and R' are each a C₁-C₄ lower alkyl, Q is selected from the group consisting of ¹³CH₂, ¹³CDH and ¹³CD₂, and Z₁ is selected from the group consisting of -S-, -S(-O)-, -S(-O)₂-, -Se-, -Se(-O)-, and -Se(-O)₂-, Z₂ is selected from the group consisting of -Si(R₆R₇R₈), -O(R₉), -Se-Ar, -Se(-O)-Ar, -Se(-O)₂-Ar, -S-Ar, -S(-O)-Ar, and -S(-O)₂-Ar wherein R₆, R₇ and R₈ are each independently selected from the group consisting of a C₁-C₄ lower alkyl, R₉ is a C₁-C₄ lower alkyl or an R₁₀-Ar group where R₁₀ is a C₁-C₄ alkylene group.