摘要 |
This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R<SUP>1</SUP>, R<SUP>2a</SUP>, R<SUP>2b</SUP>, R<SUP>2c</SUP>, R<SUP>2d</SUP>, R<SUP>3a</SUP>, R<SUP>3b</SUP>, R<SUP>3c</SUP>, and R<SUP>3d</SUP> are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed. |
申请人 |
XENON PHARMACEUTICALS INC.;CHAFEEV, MIKHAIL;CHOWDHURY, SULTAN;FRASER, ROBERT;FU, JIANMIN;KAMBOJ, RAJENDER;HOU, DUANJIE;LIU, SHIFENG;BAGHERZADEH, MEHRAN SEID;SVIRIDOV, SERGUEI;SUN, SHAOYI;SUN, JIANYU;CHAKKA, NAGASREE;HSIEH, TOM;RAINA, VANDNA |
发明人 |
CHAFEEV, MIKHAIL;CHOWDHURY, SULTAN;FRASER, ROBERT;FU, JIANMIN;KAMBOJ, RAJENDER;HOU, DUANJIE;LIU, SHIFENG;BAGHERZADEH, MEHRAN SEID;SVIRIDOV, SERGUEI;SUN, SHAOYI;SUN, JIANYU;CHAKKA, NAGASREE;HSIEH, TOM;RAINA, VANDNA |