ANTI-NONMELANOMA CARCINOMA COMPOUNDS, COMPOSITIONS, AND METHODS OF USE THEREOF

摘要

Compounds and compositions of Formula (I) are described, useful as anti- proliferative agents, and in particular anti-nonmelanoma carcinoma agents, wherein: Y^1A and Y^1B are independently Y¹; R^X1 and R^X2 are independently R^X; Y¹ is =O, -O(R^X), =S, -N(R^X), -N(O)(R^X), -N(OR^X), -N(O)(OR^X), or -N(N(R^X)( R^X)); R^X is independently R¹, R², R⁴, W³, or a protecting group; R¹ is independently -H or alkyl of 1 to 18 carbon atoms; R² is independently R³ or R⁴ wherein each R⁴ is independently substituted with 0 to 3 R³ groups or taken together at a carbon atom, two R² groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R³ groups; R³ is R^3a, R^3b, R^3c or R^3d, provided that when R³ is bound to a heteroatom, then R³ is R^3c or R^3d; R^3a is -H, -F, -CI, -Br, -I, -CF₃, -CN, N₃, -NO₂, or -OR⁴; R^3b is =O, -O(R⁴), =S, -N(R⁴), -N(O)(R⁴), -N(OR⁴), -N(O)(OR⁴), or -N(N(R⁴) (R⁴)); R^3c is - R⁴, -N(R⁴)(R⁴), -SR⁴, -S(O)R⁴, -S(O)₂R⁴, -S(O)(OR⁴), -S(O)₂(OR⁴), - OC(R^3b)R⁴, OC(R^3b)OR⁴, -OC(R^3b)(N(R⁴)(R⁴)), -SC(R^3b)R⁴, -SC(R^3b)OR⁴, - SC(R^3b)(N(R⁴)(R⁴)), -N(R⁴)C(R^3b)R⁴, -N(R⁴)C(R^3b)OR⁴, -N(R⁴)C(R^3b)(N(R⁴)(R⁴)), W³ -or R⁵W³ ; R^3d is -C(R^3b)R⁴, -C(R^3b)OR⁴, -C(R^3b)W³, -C(R^3b)OW³ or -C(R^3b)(N(R⁴)(R⁴)); R⁴ is -H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R⁵ is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W³ is W⁴ or W⁵; W⁴ is R⁶, -C(R^3b)R⁶, -C(R^3b)W⁵, -SO_M2R⁶, or -SO_M2W⁵, wherein R⁶ is R⁴ wherein each R⁴ is substituted with 0 to 3 R³ groups; W⁵ is carbocycle or heterocycle wherein W⁵ is independently substituted with 0 to 3 R² groups; and M2 is 0, 1 or 2; and pharmaceutically acceptable salts thereof.