发明名称 Quinoline derivatives as antibacterial agents
摘要 Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula; R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; R4 and R5 are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a ring; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkythioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R6 radicals may be taken together to form a bivalent radical of formula—CH═CH—CH═CH—; r is 1, 2, 3, 4 or 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo; or R8 and R9 together form the radical—CH═CH—N═.
申请公布号 AU2006263883(A1) 申请公布日期 2007.01.04
申请号 AU20060263883 申请日期 2006.06.26
申请人 JANSSEN PHARMACEUTICA N.V. 发明人 DAVID FRANCIS ALAIN LANCOIS;LEO JACOBUS JOZEF BACKX;ANIL KOUL;JEROME EMILE GEORGES GUILLEMONT;LIEVEN MEERPOEL;ISMET DORANGE;KOENRAAD JOZEF LODEWIJK MARCEL ANDRIES;MAGALI MADELEINE SIMONE MOTTE
分类号 A61K31/47;A61P31/04;C07D215/22 主分类号 A61K31/47
代理机构 代理人
主权项
地址