发明名称 |
NR-CAM GENE, NUCLEIC ACIDS AND NUCLEIC ACID PRODUCTS FOR THERAPEUTIC AND DIAGNOSTIC USES FOR TUMORS |
摘要 |
The present invention relates to the identification of a novel role of Nr-CAM in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of Nr-CAM in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for Nr-CAM. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of Nr-CAM gene expression or the inhibition of Nr-CAM activity in transformed cells reverses the transformed phenotype.
|
申请公布号 |
US2007004655(A9) |
申请公布日期 |
2007.01.04 |
申请号 |
US19990301380D |
申请日期 |
1999.04.27 |
申请人 |
MURPHY GERALD P;BOYNTON ALTON L;SEHGAL ANIL |
发明人 |
MURPHY GERALD P.;BOYNTON ALTON L.;SEHGAL ANIL |
分类号 |
A61K48/00;A61K38/00;A61P35/00;C07K14/705;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|