发明名称 |
PREPARATIONS COMPRISING ARYLAZINE SUBSTITUTED WITH A CARBONYLIC MOIETY TO INCREASE THE ACTIVITY OF GELATINASE A IN OCULAR CELLS |
摘要 |
Preparations for controlling intraocular pressure in the eye comprise as an active compound, arylazine substituted with a carbonylic moiety, which compound is capable of effecting a "pharmacological trabeculocanalotomy" in an eye by means of reducing juxtacanalicular meshwork to promote outflow of aqueous. The organic active compound increases Gelatinase A activity in ocular cells by increasing cell membrane expression of membrane-type matrix metalloproteinases (MT-MMPs) to increase aqueous outflow as a treatment for glaucoma, e.g., primary open angle glaucoma. |
申请公布号 |
WO2007002781(A2) |
申请公布日期 |
2007.01.04 |
申请号 |
WO2006US25240 |
申请日期 |
2006.06.28 |
申请人 |
BAUSCH & LOMB INCORPORATED;PFEFFER, BRUCE;FLICK, ROSEMARIE;BARTELS, STEPHEN |
发明人 |
PFEFFER, BRUCE;FLICK, ROSEMARIE;BARTELS, STEPHEN |
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