发明名称 |
Targeted retrograde gene delivery to motor neurons |
摘要 |
Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting a muscle tissue innervated by the neuron with a viral vector comprising a heterologous gene, wherein the viral vector enters said neuron and is retrogradely moved to the cell body. Additionally, methods for expressing secreted proteins from a nerve cell body as well as methods for treating neurodegenerative disorders such as amyotrophic lateral sclerosis are described.
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申请公布号 |
US2007003524(A1) |
申请公布日期 |
2007.01.04 |
申请号 |
US20060442504 |
申请日期 |
2006.05.25 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES |
发明人 |
KASPAR BRIAN K.;GAGE FRED H.;ROTHSTEIN JEFFREY D. |
分类号 |
A61K48/00;C12N15/09;A61K31/711;A61K35/76;A61K38/00;A61K38/27;A61P3/04;A61P9/10;A61P11/06;A61P25/00;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P27/02;A61P27/06;C07K14/47;C12N5/06;C12N15/861;C12N15/864 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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