USE OF CONJUGATES WITH LINKERS CLEAVABLE BY PHOTODISSOCIATION OR FRAGMENTATION FOR MASS SPECTROMETRY ANALYSIS OF TISSUE SECTIONS

摘要

The invention concerns a conjugate of formula A-X-B, wherein:
- A is a peptide tag molecule of known molecular weight,
- X is a linker that is cleaved during sample desorption/ionization, and
- B is an antibody that binds specifically to said target molecule,
and wherein said conjugate is of formula: The invention also relates to a method for determining at least one target peptide, protein, antigen or hapten map in a tissue section, comprising the use of the conjugate.