BIOSENSOR SUBSTRATE STRUCTURE FOR REDUCING THE EFFECTS OF OPTICAL INTERFERENCE

摘要

A biosensor substrate structure is provided that eliminates the effects of optical interference of light reflected from a substrate/air interface with light reflected by the biosensor's active surface (12) by incorporating a roughened or "non-specular" surface on the side of the substrate (16) opposite the biosensor' s illumination and detection apparatus (30, 38). One can generate a useful non-specular"anti-interference" surface in a number of ways in accordance with this disclosure, including (1) by adding a coating (40) of optically diffuse material, such as UV cured acrylate, to the sensor substrate (16), (2) etching or otherwise roughening the surface (17) of the sensor substrate (16), or (3) applying a grating structure to the surface (17).