发明名称 CHLORO-SUBSTITUTED GUANIDINES
摘要 The present invention relates to compounds of formula wherein R1 is hydrogen or halogen; R2 is lower alkyl; R3 is hydrogen, lower alkyl, -(CH2)n- cycloalkyl, -(CH2)n-phenyl optionally substituted by halogen, or is lower alkyl substituted by halogen, or is -(CH2)n-heterocyclyl, -(CH2)nN-di-lower alkyl, -(CH2)nNHC(O)-lower alkyl, adamantly or -(CH2)n-O-lower alkyl; n is 0 , 1, 2 or 3; and pharmaceutically acceptable acid addition salts and tautomers thereof. It has been found that the compounds of formula I have a good activity on the 5-HT5A receptor. Therefore, the invention provides the use o f a compound of formula I or a pharmaceutically acceptable salt thereof for th e treatment of diseases, related to this 15 receptor.
申请公布号 CA2612460(A1) 申请公布日期 2007.01.04
申请号 CA20062612460 申请日期 2006.06.16
申请人 F. HOFFMANN-LA ROCHE AG 发明人 LUEBBERS, THOMAS;ALANINE, ALEXANDER;STEWARD, LUCINDA;KOLCZEWSKI, SABINE;GOBBI, LUCA CLAUDIO;PETERS, JENS-UWE
分类号 C07D239/84;A61K31/517;A61P25/18;A61P25/24 主分类号 C07D239/84
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