USE OF MUTANT HERPES SIMPLEX VIRUS-2 FOR CANCER THERAPY
摘要
The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 has fusogenic activity, and comprises a modified/mutated ICP10 polynucleotide encoding a polypeptide having ribonucleotide reductase activity and lacking protein kinase activity.
申请公布号
WO2007002373(A2)
申请公布日期
2007.01.04
申请号
WO2006US24440
申请日期
2006.06.23
申请人
BAYLOR COLLEGE OF MEDICINE;ZHANG, XIAOLIU;FU, XINPING