| 发明名称 |
Methods and compositions of novel triazine compounds |
| 摘要 |
The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
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| 申请公布号 |
US2007004729(A1) |
申请公布日期 |
2007.01.04 |
| 申请号 |
US20060471099 |
申请日期 |
2006.06.20 |
| 申请人 |
TIMMER RICHARD T;ALEXANDER CHRISTOPHER W;PILLARISETTI SIVARAM;SAXENA UDAY;YELESWARAPU KOTESWAR R;PAL MANOJIT;REDDY JANGALGAR T;REDDY VELAGALA VENKATA RAMA M;ALLURI SESHA S;KUMAR POTLAPALLY R;REDDY GADDAM O |
发明人 |
TIMMER RICHARD T.;ALEXANDER CHRISTOPHER W.;PILLARISETTI SIVARAM;SAXENA UDAY;YELESWARAPU KOTESWAR R.;PAL MANOJIT;REDDY JANGALGAR T.;REDDY VELAGALA VENKATA RAMA M.K.;ALLURI SESHA S.;KUMAR POTLAPALLY R.;REDDY GADDAM O. |
| 分类号 |
A61K31/53;C07D251/44;C07D251/46;C07D251/48;C07D251/50;C07D251/52;C07D251/54;C07D251/66;C07D251/70;C07D401/04;C07D401/12;C07D401/14;C07D403/02;C07D403/04;C07D403/12;C07D403/14;C07D405/12;C07D405/14;C07D409/12;C07D409/14;C07D413/14;C07D417/04;C07D417/12;C07D417/14;C07D453/02;C07D487/04;C07F9/6521;C07F9/6558 |
主分类号 |
A61K31/53 |
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