发明名称 |
Modified antibodies against cd22 and utilization thereof |
摘要 |
CD22 diabodies, in which heavy-chain and light-chain variable regions are linked by a 5-mer linker, were produced based on known sequence information for two types of anti-CD22 antibodies. The two diabodies produced were analyzed for their activity of binding to lymphoma cells and inducing lymphoma cell death (apoptosis). As a result, both diabodies were revealed to bind to the B-lymphoma cell line, "Raji", and to have apoptosis-inducing activity towards Raji cells as well as towards another B-lymphoma cell line: Daudi cells. These results show that minibodies of antibodies that recognize CD22 can be used as apoptosis-inducing agents for tumor cells such as lymphoma cells.
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申请公布号 |
US2007003556(A1) |
申请公布日期 |
2007.01.04 |
申请号 |
US20040550934 |
申请日期 |
2004.03.31 |
申请人 |
TSUCHIYA MASAYUKI;KIMURA NAOKI;FUKUDA TATSUYA |
发明人 |
TSUCHIYA MASAYUKI;KIMURA NAOKI;FUKUDA TATSUYA |
分类号 |
A61K39/395;A61P1/04;A61P1/16;A61P3/10;A61P5/14;A61P7/00;A61P7/04;A61P7/06;A61P11/06;A61P15/08;A61P17/00;A61P17/06;A61P21/04;A61P25/00;A61P27/02;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P43/00;C07K16/28;C07K16/30 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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地址 |
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