发明名称 |
IGF-BP3-RELATED METHODS FOR INHIBITING TUMOR GROWTH |
摘要 |
The subject invention provides a method of inhibiting the proliferation of cells associated with a tumor in a subject which comprises administering to the subject between about 10 µg/kg and about 100 mg/kg of IGF-BP3, thereby inhibiting proliferation of the cells. The subject invention further provides a surgical method which comprises surgically resecting a tumor from a subject and administering to the subject between about 10 µg/kg and about 100 mg/kg of IGF-BP3, so as to inhibit metastasis of any tumor cells release din the subject's blood circulation during resection of the tumor. The subject invention further provides a surgical method which comprises performing a surgical procedure on a subject and administering to the subject between about 10 µg/kg and about 100 mg/kg of IGF-BP3, so as to inhibit proliferation of a tumor cell in the subject. The subject invention also provides an article of manufacture comprising a packaging material having therein IGF-BP3 in an amount suitable for administering a dosage to a subject of between about 10 µg/kg and about 100 mg/kg, and instructions for using the IGF-BP3 prior to, during and/or after a surgical procedure performed on the subject.
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申请公布号 |
WO2006017824(A3) |
申请公布日期 |
2007.01.04 |
申请号 |
WO2005US28090 |
申请日期 |
2005.08.05 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
KIRMAN, IRENA;WHELAN, RICHARD |
分类号 |
A61K38/00;A01N37/18;A61K39/00;C07K1/00;C07K14/00;C07K17/00 |
主分类号 |
A61K38/00 |
代理机构 |
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主权项 |
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地址 |
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