PLEUROMUTILIN DERIVATIVES CONTAINING A HYDROXYAMINO- OR ACYLOXYAMINOCYCLOALKYL GROUP

摘要

The present invention relates to Compounds of general formula (I), wherein R is hydrogen and R₁ is hydroxy or acyloxy, or R is acyl and R₁ is hydroxy or acyloxy, X is sulphur, oxygen or NR₁₀, wherein R₁₀ is hydrogen or (C_1-4)alkyl; Y is sulphur or oxygen; R₂ is hydrogen or one or more substituents, e.g. including substituents such as conventional in organic, e.g. (pleuro)mutilin, chemistry; R₄ is hydrogen or (C_1-4)alkyl; R₅ is hydrogen or (C_1-4)alkyl; R₃ and R₃' are hydrogen, deuterium, or halogen; R₆, R₇ and R₈ are hydrogen, halogen or deuterium; m is a number selected from 0 to 4, n is a number selected from 0 to 10, and p is a number selected from 0 to 10; with the proviso that n plus p are at least 1. These Compounds are usefül as pharmaceuticals, particularly as antimicrobials.