发明名称 |
STABLE TABLET DOSAGE FORMS OF PROTON PUMP INHIBITORS |
摘要 |
This invention relates to a method of making oral formulations of practically water insoluble, or very slightly water soluble proton pump inhibitors, the oral dosage forms so made, and methods of use thereof. The oral dosage form has a core tablet of compressed particles composed of powder particles of a pharmaceutically acceptable material, having coated thereon admixture of an amorphous, salt form of a benzimidazole proton pump inhibitor produced in-situ; and a pharmaceutically acceptable, water-soluble, hydrophilic polymer having a surfactant functionality. The coated core tablet has a pharmaceutically acceptable sub-coating on the core tablet; and a pharmaceutically acceptable enteric coating on the sub-coating. The coated tablet may provide enhanced absorption when administered orally.
|
申请公布号 |
WO2006101794(A3) |
申请公布日期 |
2007.01.04 |
申请号 |
WO2006US08855 |
申请日期 |
2006.03.14 |
申请人 |
QPHARMA, LLC |
发明人 |
NAMBURI, RANGA, R.;KARRI, RAMA, PRASAD;TALLAPRAGADA, RAVI, SRIKANTH;PALKHIWALA, BURGISE, F. |
分类号 |
A61K31/4439 |
主分类号 |
A61K31/4439 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|