发明名称 |
CATALYTIC ASYMMETRIC DESYMMETRIZATION OF PROCHIRAL AND MESO CYCLIC ANHYDRIDES |
摘要 |
One aspect of the present invention relates to cinchona-alkaloid-based catalysts. A second aspect of the invention relates to a method of preparing a derivatized cinchona-alkaloid catalyst. Another aspect of the present invention relates to a method of preparing a chiral, nonracemic compound from a prochiral cyclic anhydride or a meso cyclic anhydride, comprising the step of: reacting a prochiral cyclic anhydride or a meso cyclic anhydride with a nucleophile in the presence of a derivatized cinchona-alkaloid catalyst. Yet another aspect of the present invention relates to a method of kinetic resolution, comprising the step of: reacting a racemic cyclic anhydride with an alcohol in the presence of a derivatized cinchona-alkaloid catalyst. |
申请公布号 |
WO2004110609(A3) |
申请公布日期 |
2007.01.04 |
申请号 |
WO2004US18690 |
申请日期 |
2004.06.11 |
申请人 |
BRANDEIS UNIVERSITY;DENG, LI;LIU, XIAOFENG;CHEN, YONGGANG;TIAN, SHIKAI |
发明人 |
DENG, LI;LIU, XIAOFENG;CHEN, YONGGANG;TIAN, SHIKAI |
分类号 |
C07C55/00;B01J;C07C69/34;C07D453/02;C07D453/04;C07D487/00 |
主分类号 |
C07C55/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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