METHODS FOR CARBON ISOTOPE LABELING SYNTHESIS BY TRANSITION METAL-PROMOTED CARBONYLATION VIA KETENE USING DIAZO COMPOUNDS AND CARBON-ISOTOPE MONOXIDE

摘要

Methods and reagents for transition metal-promoted carbonylation via diazo compounds using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.