发明名称 |
Immune responses using compositions containing stress proteins |
摘要 |
The present invention relates to a vaccine for inducing an immune response to an antigen in a vertebrate (e.g., mammal) comprising an antigen and all or a portion of a stress protein or all or a portion of a protein having an amino acid sequence sufficiently homologous to the amino acid sequence of the stress protein to induce the immune response against the antigen. In a particular embodiment, the present invention relates to vaccines and compositions which induce a CTL response in a mammal comprising an antigen and all or a portion of a stress protein. In another embodiment, the invention relates to vaccines and compositions which induce an immune response to an influenza virus in a mammal comprising an antigen of the influenza virus and all or a portion of one or more stress proteins. The invention also relates to vaccines and compositions for inducing a CTL response to a tumor-associated antigen comprising a tumor-associated antigen and all or a portion of the stress protein. The invention also relates to vaccines and composition for suppressing allergic immune responses to allergens comprising an allergen and all or a portion of a stress protein.
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申请公布号 |
US7157089(B1) |
申请公布日期 |
2007.01.02 |
申请号 |
US19970977787 |
申请日期 |
1997.11.25 |
申请人 |
STRESSGEN BIOTECHNOLOGIES CORPORATION |
发明人 |
MIZZEN LEE;ANTHONY LAWRENCE S. D.;WU HUACHENG BILL;SIEGEL MARVIN |
分类号 |
A61K39/12;A61K38/00;A61K39/00;A61K39/145;A61K39/295;A61K45/00;A61K47/48;C07K14/11;C07K14/35 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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