发明名称 |
Complex of ras-farnesyltransferase inhibitor, a cyclodextrin, and ethanol |
摘要 |
A ras-farnesyltransferase inhibitor complex formed from a ras-farnesyltransferase inhibitor or a pharmaceutically acceptable salt thereof, a substituted cyclodextrin, and ethanol is provided. The complex has unexpectedly high aqueous solubility of the ras-farnesyltransferase inhibitor, improved dissolution, enhanced stability and is essentially free of particulate matter.
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申请公布号 |
US7157446(B2) |
申请公布日期 |
2007.01.02 |
申请号 |
US20040827952 |
申请日期 |
2004.04.20 |
申请人 |
BRISTOL MYERS SQUIBB COMPANY |
发明人 |
SMITH ANNE MARIE;CUCOLO MICHAEL;NASSAR MUNIR N. |
分类号 |
A61K31/724;A61K;A61K31/715;A61P35/00 |
主分类号 |
A61K31/724 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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