发明名称 |
MODIFIED BOUGANIN PROTEINS, CYTOTOXINS AND METHODS AND USES THEREOF |
摘要 |
<p>Modified forms of bouganin protein are provided having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. Also provided are T-cell epitope peptides of bouganin, and modified T-cell epitope peptides of bouganin, which have a reduced propensity to activate human T cells as compared to the non-modified T-cell epitope peptide. Also provided are cytotoxins that comprise a ligand which binds to cancer cells, and is attached to modified bouganin proteins. Also provided are methods of inhibiting or destroying mammalian cancer cells using the cytotoxins and pharmaceutical compositions for treating human cancer. ® KIPO & WIPO 2007</p> |
申请公布号 |
KR20070000494(A) |
申请公布日期 |
2007.01.02 |
申请号 |
KR20067021711 |
申请日期 |
2005.03.18 |
申请人 |
MERCK PATENT GMBH |
发明人 |
BAKER MATTHEW;CARR FRANCIS J.;HELLENDOORN KOEN;CIZEAU JEANNICK;MACDONALD GLEN CHRISTOPHER;ENTWISTLE JOYCELYN;BOSC DENIS GEORGES;GLOVER NICHOLAS RONALD |
分类号 |
C07K14/415;A61K38/00;A61K38/16;A61K39/395;A61K47/48;A61P35/00;C07K7/08;C07K16/30;C07K16/44;C07K19/00;C12N15/11;C12N15/13;C12N15/29;C12N15/62 |
主分类号 |
C07K14/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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