NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

摘要

A compound of formula (I), wherein B is a phenyl ring, a 5 to 10 membered heteroaromatic group containing one or more heteroatoms, or a naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl, benzo[1,3]dioxolyl, or biphenyl group; R₁, R₂ and R₃ each independently represent a hydrogen or halogen atom, or a hydroxy group, a phenyl group, -OR⁷, -SR⁷, -NR⁷R⁸, -NHCOR⁷, -CONR⁷R⁸, -CN, -NO₂, -COOR⁷ or CF₃ group, or a strait or branched, substituted or unsubstituted lower alkyl group, wherein R⁷ and R⁸ each independently represent a hydrogen atom, a straight or branched lower alkyl group, or together form an alicyclic ring; or R¹ and R² together form an aromatic or alicyclic ring or a heterocyclic group. n is an integer from 0 to 4; A represents a group selected from -CH₂-, -CH-CR⁹-, -CR⁹-CH-, -CR⁹R¹⁰-, -CO-, -O-, -S-, -S(O)-, -S(O)₂- and NR⁹, wherein R⁹ and R¹⁰ each independently represent a hydrogen atom, a straight or branched lower alkyl group, or together form an alicyclic ring; m is an integer from 0 to 8, provided that when m=0, A is not -CH₂-; p is an integer from 1 to 2 and the substitution in the azonia bicyclic ring may be in the 2, 3 or 4 position including all possible configurations of the asymmetric carbons; R₄ represents a group of structure: (Formulae II) wherein R¹¹ represents a hydrogen or halogen atom, a hydroxy group, an alkoxy group, a nitro group, a cyano group, -CO₂R¹² or -NR¹²R¹³, wherein R¹² and R¹³ are identical or different and are selected from hydrogen and straight or branched lower alkyl groups, or a straight or branched, substituted or unsubstituted lower alkyl group; R⁵ represents an alkyl group of 1 to 7 carbon atoms, an alkenyl group containing 2 to 7 carbon atoms, or a group of formula (III) wherein q=1 or 2 and R¹¹ iss a defined above; R⁶ represents a hydrogen atom, a hydroxy group, a methyl group or a -CH₂OH group; and X^- represents a pharmaceutically acceptable anion of a mono or polyvalent acid .