| 发明名称 |
FAP ALPHA-SPECIFIC ANTIBODY WITH IMPROVED PRUDUCIBILITY |
| 摘要 |
Recombinant antibody proteins are provided that specifically bind fibroblast activation protein alpha (FAPalpha) and comprise framework modifications resulting in the improved producibility in host cells. The invention also relates to the use of said antibodies to diagnostics and therapeutic purposes and methods of producing said antibodies.
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| 申请公布号 |
BG65034(B1) |
申请公布日期 |
2006.12.29 |
| 申请号 |
BG20000104828 |
申请日期 |
2000.10.05 |
| 申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
PARK JOHN;GARIN-CHESA PILAR;BAMBERGER UWE;RETTIG WOLFGANG;LEGER OLIVIER;SALDANHA JOSE |
| 分类号 |
C07K16/00;G01N33/574;A61K38/00;A61K39/395;A61K47/48;A61K49/00;A61K51/10;A61P35/00;C07K16/18;C07K16/40;C07K16/46;C07K19/00;C12N5/10;C12N15/09;C12N15/13;C12N15/62;C12N15/85;C12P21/02;C12Q1/02;G01N33/577 |
主分类号 |
C07K16/00 |
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