COMPETITIVE REGULATION OF HEPCIDIN MRNA BY SOLUBLE AND CELL-ASSOCIATED HEMOJUVELIN

摘要

Disclosed herein are hemojuvelin-specific siRNAs that vary hemojuvelin mR NA concentration. Also disclosed herein, GPI-hemojuvelin positively regulated hepcidin mRNA expression, independently of the IL-6 pathway, whereas soluble hemojuvelin ( s- hemojuvelin) suppressed hepcidin mRNA expression in primary human hepatocytes in a log- linear dosedependent manner. Disclosed are compositions and methods for modulating diseases of iron metabolism and hepcidin expression or hepcidin levels.