| 摘要 |
THE PRESENT INVENTION RELATES TO COMPOUNDS OF FORMULA (&Igr;) THEIR PRODRUGS, N-OXIDES, ADDITION SALTS, QUATERNARY AMINES AND STEREOCHEMICALLY ISOMERIC FORMS, WHEREIN THE BIVALENT RADICAL REPRESENTS A SATURATED OR AN UNSATURATED HOMOPIPERIDINYL HAVING ONE DOUBLE BOND, AND WHEREIN SAID BIVALENT RADICALIS SUBSTITUTED WITH R2 BEING HYDROGEN, HYDROXY, C1-4ALKYL, OR C1-4ALKYLOXY; -A1=A2=A3=A4- REPRESENTS AN OPTIONALLY SUBSTITUTED BIVALENT RADICAL; R1 IS HYDROGEN, C1-6ALKYL, ARYL1, C1-6ALKYL SUBSITUTED WITH ARYL1, C1-4 ALKYLOXYCARBONYL, ARYL1CARBONYL, ARYL1C1-6ALKYARBONYLC1-4ALKYLCARBONYL,TRIFLUOROMETHYL,TRIFLUOROMETHYLCARBONYL,C1-6ALKYLSULFONYL,ARYL1SULFONYL,METHANESULFONYL,BENZENESULFONYL,TRIFLUOROMETHANESULFONYL,DIMETHYLSULFAMOYL; X REPRESENTS O, S OR NR3, WHEREIN R3 IS HYDROGEN, C1-6ALKYL, METHASULFONYL, BENZENESULFONYL, TRIFLUOROMETHANESULFONYL, DIMETHYSULFAMOYL, C1-4ALKYL SUBSTITUTED WITH ARYL2 AND OPTIONALLY WITH HYDROXY, C1-4ALKYCARBONYLC1-4ALKYL SUBSTITUTED WITH ARYL2; ARYL1 IS OPTIONALLY SUBSTITUTED PHENYL,OPTIONALLY SUBSTITUTED PYRIDINYL, NAPHTHYL, QUINOLINYL, OR 1,3-BENZODIOXOLYL; ARYL2IS OPTIONALLY SUBSTITUTED PHENYL; FUNDIC RELAXATING ACTIVITY. PROCESSES FOR PREPARING SAID PRODUCTS, FORMLATIONSCOMPRISINGNSAID PRODUCTS AND THEIR USE AS A MEDICINE ARE DISCLOSED, IN PARTICULAR FOR TREATING DYSPEPTIC SYMTOMS, IRRITABLE BOWEL SYNDROME AND OTHER CONDITIONS RELATED TO A HAMPERED OR IMPAIRED RELAXATION OF THE FUNDUS.
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