TARTRATE SALTS OF 5,8,14-TRIAZATERACYCLO [10.3.1.02,11.04,9]-HEXADECA-2(11),3,5,7,9-PENTAENE AND PHARMACEUTICAL COMPOSITIONS THEREOF

摘要

THE PRESENT INVENTION IS DIRECTED TO THE TARTRADE SALTS OF 5,8,14-TRIAZATETRACYCLO[10.3.1.0211.04,9]-HEXADECA-2(11),3,5,7,9-PENTAENE: AND PHARMACEUTICAL COMPOSITION THEREOF. THE PRESENT INVENTION IS PARTICULAR IS DIRECTED TO THE L-TARTRATE SALT, AND FURTHER TO THE VARIOUS POLYMORPHS OF THE L-TARTRATE SALT, INCLUDING TWO DISTINCT ANHYDROUS POLYMORPHS (REFERRED TO HEREIN AS FORMS A AND B) AND A HYDRATE POLYMORPHS (REFERRED TO HEREIN AS FORM C). IN ADDITION, THE PRESENT INVENTION IS ALSO DIRECTED TO THE D-TARTRATE SALT OF 5,8,14-TRIAZATETRACYCLO [10.3.1.02,11.04,9]-HEXADECA-2(11), 3,5,7,9-PENTAENE AND THE VARIOUS POLYMORPHS THEREOF; AS WELL AS THE D,L-TARTRATE SALT THEREOF AND ITS POLYMORPHS, AND THE MESO-TARTRATE SALT THEREOF AND ITS POLYMORPHS.