发明名称 |
SUBSTITUTED -4-PHENYL-4-(1H-IMIDAZOL-2-YL)-PIPERIDINE DERIVATIVES FOR REDUCING ISCHAEMIC DAMAGE |
摘要 |
The present invention relates to an agent for reducing ischaemic damage to an organ, in particular to a heart and a brain, pharmaceutical compositions comprising said agent and the use of said agent for the treatment of ischaemic diseases to the heart and the brain. The agent comprises a substituted 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivative according to Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof, the N-oxide forms thereof and the prodrugs thereof. In particular are claimed the compounds according to Formula (I) in which A=B is C=O or SO, X is a covalent bond, Ris alkyloxy, alkyloxyalkyl, Ar or NRR, wherein Rand Reach independently are hydrogen or Ar ; or A=B and Rtogether form a benzoxazolyl radical ; p is zero, Ris benzyl optionally substituted with hydroxy, alkyl or alkyloxycarbonyl and Rand Reach are hydrogen. The use of said agents has important clinical ramifications with regard to the reduction of ischaemic damage to an organ in a mammal, in particular to a heart and/or a brain, the prevention of coronary artery diseases in a mammal by inducing a cardioprotective effect and the treatment and prevention of stroke. |
申请公布号 |
EA007657(B1) |
申请公布日期 |
2006.12.29 |
申请号 |
EA20040000547 |
申请日期 |
2002.10.10 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
JANSSENS FRANS, EDUARD;LEENAERTS JOSEPH, ELISABETH;FERNANDEZ-GADEA FRANCISCO, JAVIER;GOMEZ-SANCHEZ ANTONIO;FLAMENG WILLEM;HERIJGERS PAUL, JOHANNES, LUDOVICUS;MEERT THEO, FRANS;BORGERS MARCEL, J., M. |
分类号 |
A61K31/454;C07D401/04;A61K31/4545;A61K31/506;A61P9/00;A61P9/10;A61P43/00;C07D401/14;C07D413/14;C07D417/14 |
主分类号 |
A61K31/454 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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