A MIXTURE OF MEDICAMENT QUALITY CONTROL “0.1 G SUBLINGUAL GLYCINE TABLETS” AND METHOD FOR PREPARING THEREOF

摘要

The invention relates to chemico-pharmaceutical industry, more definite to a mixture for a medicament quality control “0.1 g. sublingual glycine tablets” and a method for preparing thereof. The method comprises a mixture preparing by dissolving 2.5 g. of tablets crushed to powder in 250 ml of purified water and measuring light-scattering using a spectrophotometer with wave length 700±2 nm in a cuvette with 10 mm layer thickness respective to the purified water. The dilution of the 2.5 g. of tablets are carried out at 37°C during 20 min. in an device for determining dilution using an impeller mixer at 150 rev/min. After the dilution the mixture is maintained for 10 minutes, then 4 ml is sampled for determining light scattering . The quality control mixture comprises the ratio 100:1 between water and the crushed powder tablet comprising 0.101 g. microcapsules of non-sintered crystals of aminoacetic acid coated with a polymeric methylcellulose film of MC-100 grade, and 0.001 magnesium stearate. The light scanning coefficient compared to the purified water is within between 50 to 70% at the wave length 700±2 nm for 4 ml mixture at 10 mm layer thickness.