MULTI-COMPARTMENT DELIVERY

摘要

Devices designed to effectively deliver multiple biological entities in combination for tissue engineering, and methods and uses of such devices are provided. The devices are capable of delivering cells or clusters of cells, such as islets of Langerhans, in combination with a therapeutic compound, such as an angiogenic growth factor , for the purpose of transplantation. The devices are composed of at least two compartments that are designed independently and processed separately in order to accommodate different requirements of the biological entities. The compartments of the device can be combined prior to or at the time of implantation, such that the therapeutic released from one compartment provides some benefit to cells hosted by another compartment to promote or improve their proliferation, differentiation, survival, or functionality.