摘要 |
The invention provides compounds of the formula (I),R1 is hydrogen,Calkyl,Ccycloalkyl,Ccycloalkyl-C-alkyl,C-alkoxy,Calkoxy-Calkyl,Calkoxycarbonyl, fluoroCalkyl,R2 is hydrogen,Calkyl,C-cycloalkyl,Ccycloalkyl-Calkyl,Calkoxycarbonyl, halogen, fluoro-Calkyl or cyanomethyl,R3 is1-4C-alkoxy-C-alkyl,Calkoxy-Calkoxy-Calkyl,C alkoxycarbonyl, fluoro-C-alkoxy-C-alkyl or the radical-CO-NR31 R32, whereR 31 is hydrogen,Calkyl,C-alkoxy-Calkyl andR32 is hydrogen,Calkyl orCalkoxy-C-alkyl, or whereR31 and R32 together and including the nitrogen atom to which they are attached form a pyrrolidino, piperidino or morpholino radical,Arom is a R4-, R5-, R6-and R7-substituted mono-or bicyclic aromatic radical selected from the group consisting of phenyl, naphthyl, pyrrolyl, pyrazolyl, imidazolyl, 1,2, 3-triazolyl, indolyl, benzimidazolyl, furanyl (furyl), benzofuranyl (benzofuryl), thiophenyl (thienyl), benzothiophenyl (benzothienyl), thiazolyl, isoxazolyl, pyridinyl, pyrimidinyl, quinolinyl and isoquinolinyl, whereR4 is hydrogen,Calkyl,C-alkoxy,Calkenyloxy,Calkylcarbonyl, carboxyl,Calkoxycarbonyl, carboxy-Calkyl,Calkoxycarbonyl-Calkyl, halogen, hydroxyl, aryl, aryl-Calkyl, aryloxy, aryl-Calkoxy, trifluoromethyl, nitro, amino, mono or di-Calkylamino,Calkylcarbonylamino,Calkoxycarbonylamino,C-alkoxy-Calkoxycarbonylamino or sulfonyl,R5 is hydrogen,Calkyl,Calkoxy,Calkoxycarbonyl, halogen, trifluoromethyl or hydroxyl,R6 is hydrogen,Calkyl or halogen andR7 is hydrogen,Calkyl or halogen, wherearyl is phenyl or substituted phenyl having one, two or three identical or different substituents from the group consisting ofCalkyl,Calkoxy, carboxyl,Calkoxycarbonyl, halogen, trifluoromethyl, nitro, trifluoromethoxy, hydroxyl and cyano,X is O (oxygen) or NH, and salts thereof.The described compounds inhibit the secretion of gastric acid. |