HISTONE DEACETYLASE INHIBITORS CAUSING CELLS DIFFERENTIATING

摘要

The present invention provides the compound having formula (I),wherein each of Rand Ris phenyl, cyclohexyl, cyclohexylamino, naphtha, pyridineamino, piperidino, 9-purine-6-amine, thiazoleamino group, hydroxyl, branched or unbranched alkyl, alkenyl, alkyloxy, benzyloxy, phenylalkyloxy, pyridine, quinolyl or thieno groups, in which alkyl is methyl, ethyl, or t-butyl;where Ris hydroxylamino-, hydroxyl, amino-, alkylamino- or alkyloxy- group, in which alkyl is methyl, ethyl, or t-butyl; where Ris a hydogen atom, halo, phenyl group or cyclohexyl group; where A may be the same or different and represents an amide moiety, -O-, -S-, -NR, or –CH-, where Ris C-Calkyl and wherein n is an integer from 3 to 10; and wherein phenyl, naphtha, quinolyl, alkyl or cyclohexyl groups can be substituted by dimethylamino group or a pharmaceutically acceptable salt thereof.The present invention also provides a method of selectively inducing growth arrest, terminal differentiation and/or apoptosis of neoplastic cells and thereby inhibiting proliferation of such cells, and moreover for treating a patient having a tumor characterized by proliferation of neoplastic cells, for differentiotion of neoplastic cells in tumor and for inhibiting the activity of histone deacetylase.Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.