GENETIC POLYMORPHISMS ASSOCIATED WITH MYOCARDIAL INFARCTION AND USES THEREOF

摘要

A myocardial infarction related single nucleotide polymorphism and a haplotype thereof are provided to be able to predict the attack probability of the myocardial infarction and genetic sensitivity, thereby being used for diagnosing the myocardial infarction and screening medicines for treating the myocardial infarction. The myocardial infarction related single nucleotide polymorphism comprises a polynucleotide including at least 8 continuous polynucleotides containing each 101th nucleotide in a polynucleotide selected from the group consisting of SEQ ID : NOs. 1-7, 9, 10 and 14, and a complimentary polynucleotide thereof. The method for identifying a subject having a modified danger degree of myocardial infarction attack comprises the steps of: (a) isolating a nucleic acid sample from the subject to de diagnosed; and (b) determining a genotype of a polymorphic site of the each 101th nucleotide in the polynucleotide selected from the group consisting of SEQ ID : NOs. 1-7, 9, 10 and 14 or a polynucleotide consisting of SEQ ID : NOs. 1-14.