RECEPTOR ANTAGONISTS FOR TREATMENT OF METASTATIC BONE CANCER

摘要

The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering an IGF-IR antagonist and/or a PDGFR.alpha. antagonist. The invention also provides antibodies that bind to human PDGFR.alpha. and neutralize activation of the receptor. The invention further provides a methods for neutralizing activation of PDGFR.alpha., and a methods of treating a mammal with a neoplastic disease using the antibodie alone or in combination with other agents.