| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a versatile vector for transporting a suicide gene to the tumor part. <P>SOLUTION: The expression vector is derived from mesenchymal stem cell and contains a suicide gene such as herpes virus thymidine kinase (HSVtk) gene. The enzyme (such as HSVtk) generated by the expression of the suicide gene converts a prodrug (gangcyclovir (GCV), etc.) of an agent to kill or inhibit the proliferation of the target tumor cell into a drug having pharmacological activity (cytotoxicity). In spite of the use of an extremely easily available mesenchymal stem cell, the expression vector has excellent bystander effect compared with conventional case to use neural stem cell. <P>COPYRIGHT: (C)2007,JPO&INPIT</p> |
