发明名称 Vaccine composition comprising Flt3-ligand
摘要 Flt3-ligand can be used to generate large numbers of dendritic cells from hematopoietic progenitor and stem cells. Flt3-ligand can be used to augment immune responses in vivo, and expand dendritic cells ex vivo. Such dendritic cells can then be used to present tumor, viral or other antigens to naive T cells, can be useful as vaccine adjuvants. When flt3-L is used and/or administered in combination with other reactive agents, e.g. CD40 binding proteins, 4-1BBL or antibodies reactive with 4-1BB, CD30 ligand antagonists, RANKL, and/or interferon alpha the combination further enhances immune responses and the effectiveness of vaccine adjuvants.
申请公布号 US2006292166(A1) 申请公布日期 2006.12.28
申请号 US20060510651 申请日期 2006.08.28
申请人 发明人 LYNCH DAVID H.;BORGES LUIS;MILLER ROBERT E.;MALISZEWSKI CHARLES R.
分类号 A61K39/12;A61K39/00;A61K39/02 主分类号 A61K39/12
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